1137634-A1 is referenced by 1 patents.

This invention provides a process for preparing the hypocholesterolemic compound (I) comprising: (a) reacting p-fluorobenzoylbutyric acid with pivaloyl chloride and acylating the product with a chiral auxiliary to obtain a ketone of formula (IV); (b) reducing the ketone of formula (IV) in the presence of a chiral catalyst to an alcohol; (c) reacting the chiral alcohol of step (b), an imine and a silyl protecting agent, then condensing the protected compounds to obtain a beta -(substituted-amino)amide of formula (VII); (d) cyclizing the beta -(substituted-amino)amide of formula (VII) with a silylating agent and a fluoride ion catalyst to obtain a protected lactam of formula (VIII); and removing the protecting groups. The intermediates of formulas (VII and VIII) are also claimed.

Title
Process for the synthesis of azetidinones
Application Number
EP19990963973 19991206
Publication Number
1137634 (A1)
Application Date
December 6, 1999
Publication Date
October 4, 2001
Inventor
Colon Cesar
US
Chiu John S
US
Mcallister Timothy L
US
Tann Chou Hong
US
Fu Xiaoyong
US
Thiruvengadam Tiruvettipuram K
US
Assignee
Schering
US
IPC
C07D 205/08
C07F 07/00
C07B 61/00
C07D 205/00
C07F 07/18
C07B 61/00
C07D 205/08
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