1001027-A2 is referenced by 7 patents and cites 3 patents.

Production, and improvement, of panthothenic acid (I)-producing microorganisms by amplifying (particularly overexpressing) sequences (I) that encode ketopanthoate reductase (KPR), specifically the panE gene, either individually or together. Optionally the ilvC gene is also amplified. Independent claims are also included for the following: (1) plasmid vectors pFE80, pFE65 and pFE32, deposited, in Escherichia coli K12 strain MG1655, as DSM 12414, 12382 and 12413, respectively; (2) the E. coli K12 strain FE6 which is resistant to valine; (3) the E. coli strain FE7 in which the avtA gene is exchanged for a avtA::aadB fragment (deposited as DSM 12380); (4) a host microorganism (E. coli or Corynebacterium) that contains one of the specified plasmids and is optionally resistant to one or more metabolites and/or antimetabolites; ; C. glutamicum ATCC13032/pFE91, where pFE91 includes the C. glutamicum ilvC gene; and (5) production of (I) by culturing any of the specified microorganisms and isolation of (I) from medium or cells.

Title
Process for the reduction of pantothenic acid by amplification of nucleotide sequences coding for ketopantoate-reductase
Application Number
EP19990118670 19990922
Publication Number
1001027 (A2)
Application Date
September 22, 1999
Publication Date
May 17, 2000
Inventor
Thierbach Georg Dr
DE
Farwick Mike Dr
DE
Dohmen Juergen Dr
DE
Dusch Nikole Dr
DE
Puehler Alfred Prof Dr
DE
Kalinowski Joern Dr
DE
Elischewski Frank Dr
DE
Assignee
Degussa
DE
IPC
C12P 13/02
C12P 07/42
C12N 15/70
C12N 15/67
C12N 01/21
C12N 15/53
C12Q 01/68
C12P 13/00
C12P 07/40
C12N 15/70
C12N 15/53
C12N 15/52
C12N 09/88
C12N 09/04
C12N 09/02
C12N 09/00
C12N 01/21
C12N 15/09
C12Q 01/68
C12P 13/02
C12P 07/42
C12N 15/70
C12N 15/53
C12N 15/52
C12N 09/88
C12N 09/04
C12N 09/02
C12N 09/00
C12N 01/21
C12N 15/09
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