0969011-A2 is referenced by 7 patents and cites 9 patents.

Described is a process for the regioselective dehydration of 11-hydroxy steroids using PCl5, PCl3, POCl3 or either SO2Cl2 and imidazole, or PPh3 and CCl4. The disclosed process selectively forms DELTA steroids from either 11- alpha - or 11- beta -hydroxy steroids, and can also be used for the one-step conversion of 11,21-dihydroxy steroids to 21-chloro- DELTA steroids. Also disclosed are processes for the regioselective conversion of 11- beta -chloro steroids to DELTA steroids, and for regioselectively converting an 11,17,21-trihydroxy steroid to a 21-chloro-11,17-dihydroxy steroid.

Title
Process for preparing delta 9,11 and 21-chloro corticosteroids
Application Number
EP19990108236 19950530
Publication Number
0969011 (A2)
Application Date
May 30, 1995
Publication Date
January 5, 2000
Inventor
Colon Cesar
US
Lee Junning
US
Tann Chou Hong
US
Thiruvengadam Tiruvettipuram K
US
Fu Xiaoyong
US
Assignee
Schering
US
IPC
C07J 51/00
C07J 07/00
C07J 05/00
C07J 51/00
C07J 07/00
C07J 05/00
C07J 51/00
C07J 07/00
C07J 05/00
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