0806212-A1 is referenced by 41 patents and cites 6 patents.

The invention provides an implantable device coated with a layer of calcium phosphate and optionally one or more biologically active substances such as growth factors, lipis, (lipo)polysaccharides, hormones, proteins, antibiotics or cytostatics. The device can be obtained by a nanotechnology process comprising subjecting a substrate to a surface treatment until a surface roughness with an average peak distance (Ra value) between 10 and 1,000 nm and subjecting the roughened surface to precipitation of calcium phosphate from a solution containing calcium and phosphate ions with optional coprepitation of the biologically active substance.

Title
Device for incorporation and release of biologically active agents
Application Number
EP19970201425 19970512
Publication Number
0806212 (A1)
Application Date
May 12, 1997
Publication Date
November 12, 1997
Inventor
de Groot Klaas
NL
Wen Hai Bo
NL
de Bruijn Joost Dick
NL
Leitao Eugenia Ribeiro de Sous
GB
Assignee
Matrix Medical
NL
IPC
A61F 02/30
A61L 27/00
A61L 27/00
A61F 02/30
A61L 27/54
A61L 27/32
A61F 02/30
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