0801060-A1 is referenced by 77 patents and cites 5 patents.

The present invention relates to certain compounds of the formula (I) the racemic-enantiomeric mixtures and optical isomers of said compounds and the pharmaceutically acceptable salts or prodrugs thereof, depicted below, which are beta -adrenergic receptor agonists and accordingly have utility as, inter alia, hypoglycemic and antiobesity agents. More specifically, the compounds of the instant invention are selective agonists of beta 3-adrenergic receptor. The invention also relates to methods of use for the compounds and to pharmaceutical compositions containing them. The compounds of the present invention also possess utility for increasing lean meat deposition and/or improving the lean meat to fat ratio in animals, e.g., ungulate animals, companion animals and poultry. The compounds have the formula wherein R, R, R, R, R, Y and Z are as defined in the specification.

Title
Heterocyclic beta-3 adrenergenic agonists
Application Number
EP19970200858 19970324
Publication Number
0801060 (A1)
Application Date
March 24, 1997
Publication Date
October 15, 1997
Inventor
Wright Stephen W
US
Dow Robert L
US
Assignee
Pfizer
US
IPC
C07D 311/00
C07D 307/00
C07D 215/00
C07D 213/00
C07D 209/00
A61P 25/00
A61P 13/00
A61P 03/00
C07D 311/66
C07D 311/04
C07D 307/85
C07D 307/78
C07D 215/48
C07D 213/40
C07D 209/42
A61P 43/00
A61P 25/26
A61P 25/24
A61P 15/00
A61P 13/02
A61P 11/00
A61P 03/06
A61P 03/04
A61P 01/00
A61K 31/47
A61K 31/404
A61K 31/403
A61K 31/40
A61K 31/352
A61K 31/35
A61K 31/343
A61K 31/34
View Original Source Download PDF