Polyester matrix for a pharmaceutical sustained-release preparation. EPO Patent 0668073-A2

0668073-A2 is referenced by 8 patents and cites 4 patents.

The present invention relates to a matrix for sustained-release preparation comprising an ester formed at a terminal carboxyl group of a straight-chain polyester which essentially consists of an alpha -hydroxymonocarboxylic acid. The matrix is stable to light, heat, moisture, coloring etc., and is of low toxicity. The sustained-release preparation produced by using the ester of the present invention offers stable drug release over an extended period of time, ensuring sustained stable effect. Furthermore, the sustained-release preparation does not show excess drug release just after administration.

Title
Polyester matrix for a pharmaceutical sustained-release preparation.
Application Number
EP19950301091 19950221
Publication Number
0668073 (A2)
Application Date
February 21, 1995
Publication Date
August 23, 1995
Inventor
Sano Atsunori
JP
Oka Masahisa
JP
Kamei Shigeru
JP
Okamoto Kayoko
JP
Saikawa Akira
JP
Igari Yasutaka
JP
Assignee
Wako Pure Chem
JP
Takeda Chemical
JP
IPC
A61K 47/34
A61K 09/50
A61K 09/22
A61K 09/16
C08G 63/00
A61K 09/16
C08G 63/06
A61K 09/16
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Citations: 8

  1. Celal Albayrak: Induced phase transition method for the production of microparticles containing hydrophobic active agents. Nektar Therapeutics, May 31, 2005: US06899898 (20 worldwide citation)
  2. Georg Rössling, Celal Albayrak, Johannes Tack, Reinhard Schmitz: Process for the production of morphologically uniform microcapsules and microcapsules that are produced according to this process. Actipac Biosystems, Michael J Rafa, Felissa H Cagan, June 3, 2003: US06572894 (18 worldwide citation)
  3. James S Stefely, David W Schultz, Luke E Schallinger, Craig A Perman, Chester L Leach, Daniel C Duan: Medicinal aerosol solution formulation with biocompatible polymer. 3M Innovative Properties Company, Ted K Ringsred, MarySusan Howard, Robert W Sprague, July 9, 2002: US06416742 (15 worldwide citation)
  4. Yamamoto Kohei, Tani Tsutomu, Aoki Takashi, Hata Yoshio: Lactic acid polymer and process for producing the same. Wako Pure Chem, Takeda Chemical Industries, May 14, 2003: EP1310517-A1 (13 worldwide citation)
  5. Kohei Yamamoto, Tsutomu Tani, Takashi Aoki, Yoshio Hata: Lactic acid polymer and process for producing the same. Wako Pure Chemical, Takeda Pharmaceutical Company, Wenderoth Lind & Ponack L, March 28, 2006: US07019106 (10 worldwide citation)
  6. Yoshio Hata, Yasutaka Igari: Process for producing polymer. Takeda Chemical, Wenderoth Lind & Ponack L, June 29, 2004: US06756472 (5 worldwide citation)
  7. Celal Albayrak: Induced phase transition method for the production of microparticles containing hydrophilic active agents. Alrise Biosystems, Kagan Binder PLLC, August 7, 2007: US07252842 (4 worldwide citation)
  8. Stefely James S, Schultz David W, Schallinger Luke E, Perman Craig A, Leach Chester L, Duan Daniel C: Biocompatible compounds for pharmaceutical drug delivery systems. Minnesota Mining & Mfg, August 8, 2007: EP1815845-A2

References: 4

  1. Yamada Minoru, Ishiguro Seiko, Ogawa Yasuaki: Prolonged release preparation and polymers thereof.. Takeda Chemical Industries, April 22, 1992: EP0481732-A1 (51 worldwide citation)
  2. Okada Hiroaki, Ogawa Yasuaki, Yashiki Takatsuka: Method for producing microcapsule.. Takeda Chemical Industries, June 19, 1985: EP0145240-A2 (61 worldwide citation)
  3. FR2537980
  4. CH672133