0649628-A1 is referenced by 12 patents and cites 6 patents.

The present invention provides a process and devices for continuously measuring the concentration of an analyte in tissue, which comprises providing said tissue with a hollow fiber having a pore size between the size of the analyte and the size of macromolecules, perfunding said hollow fiber with a solution compatible with the tissue, leading that solution from the hollow fiber through a reactor for the analyte, which reactor comprises a second hollow fiber having a pore size between the size of the analyte and the size of macromolecules, said hollow fiber being located in a container which comprises macromolecular reactants for detecting the analyte and a signal producing system coupled therewith, after which the perfusion fluid is lead from the reactor to an eliminator for the analyte,; whereby at least 95% of the remaining analyte is removed from the perfusion fluid and reintroducing said perfusion fluid in said first hollow fiber. This is a closed circuit and therefore this method can be continued over a longer period of time than the methods of the prior art, without the need to replace reservoirs.

Title
Processes and devices for continuously monitoring levels of anolyte.
Application Number
EP19930202972 19931022
Publication Number
0649628 (A1)
Application Date
October 22, 1993
Publication Date
April 26, 1995
Inventor
Wientjes Klaas Jan Cornelis
NL
Schmidt Fransiscus Josephus
NL
Schoonen Adelbert Josef Martin
NL
Assignee
Univ Groningen
NL
Siemens Elema
SE
IPC
A61B 05/00
A61M 01/36
A61B 05/00
A61B 05/145
A61M 01/36
A61B 05/1486
A61B 05/1473
A61B 05/00
A61B 05/145
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