0640647-A2 is referenced by 48 patents and cites 5 patents.

The present invention pertains to the use of glycosaminoglycans, chemically derivatized glycosaminoglycans, and optionally, chemically derivatized collagens to form ionically crosslinked gels useful in mammal soft tissue augmentation and in drug delivery systems. The derivatized glycosaminoglycans can be used to form an ionically homogeneous gel comprising one or more species of glycosaminoglycan derivative or can be used to form an ionically crosslinked heterogeneous gel comprising one or more negatively charged species of glycosaminoglycan or collagen derivative in combination with one or more positively charged species of glycosaminoglycan derivative or collagen derivative. The ionically crosslinked homogeneous or ionically crosslinked heterogeneous gels are produced from liquid solutions which upon adjusting pH in situ form a gel.

Title
Ionically crosslinked glycosaminoglycan gels for soft tissue augmentation and drug delivery.
Application Number
EP19940112944 19940818
Publication Number
0640647 (A2)
Application Date
August 18, 1994
Publication Date
March 1, 1995
Inventor
Rhee Woonza M
US
Berg Richard A
US
Assignee
Collagen
US
IPC
C08L 89/06
C08L 05/10
C08L 05/10
A61L 27/00
A61K 47/36
C08L 05/08
C08L 05/00
A61L 27/00
A61K 47/36
A61K 09/00
C08B 37/00
C08L 05/10
C08L 05/08
A61L 27/54
A61L 27/26
A61K 47/36
A61K 09/00
C08B 37/00
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