0636370-A1 is referenced by 89 patents and cites 4 patents.

In order to provide a sustained release pharmaceutical formulation containing morphine which is suitable for administration on a once daily basis, in a first aspect, an orally administrable sustained release dosage unit form contains morphine, or a pharmaceutically acceptable salt thereof, as active ingredient, which formulation gives a peak plasma level at 1.0 to 6 hours after administration. In a second aspect, the formulation contains an effective amount of morphine or a pharmaceutically acceptable salt thereof, characterised by a W50 for the M-6-G metabolite or for morphine of between 4 and 12 hours.; In a third aspect, the pharmaceutical dosage unit form is obtainable by compressing multiparticulates comprising a pharmaceutically active substance in a matrix of hydrophobic fusible material having a melting point of from 35 to 150 DEG C, the dosage form optionally containing conventional tabletting excipients.; In a further aspect of the invention, sustained release multiparticulates containing morphine or a pharmaceutically acceptable salt thereof are produced by mechanically working in a high-speed mixer a mixture of particulate morphine or a pharmaceutically acceptable salt thereof and a particulate, hydrophobic fusible carrier or diluent having a melting point from 35 to 150 DEG C and optionally a release control component comprising a water soluble fusible material or a particulate soluble or insoluble organic or inorganic material at a speed and energy input which allows the carrier or diluent to melt or soften whereby it agglomerates, and breaking down the agglomerates to give controlled release particles.

Title
Sustained release compositions containing morphine.
Application Number
EP19940304144 19940609
Publication Number
0636370 (A1)
Application Date
June 9, 1994
Publication Date
February 1, 1995
Inventor
Kaiko Robert
US
Sackler Richard
US
Pedi Frank Jr
US
Oshlack Benjamin
US
Goldenheim Paul
US
Chasin Mark
US
Smith Kevin John
GB
Prater Derek Allan
GB
Miller Ronald Brown
CH
Malkowska Sandra Therese A
GB
Leslie Stewart Thomas
GB
Knott Trevor John
GB
Heafield Joanne
GB
Assignee
Euro Celtique
LU
IPC
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