0620432-A1 is referenced by 41 patents and cites 2 patents.

In a method for controlling sample introduction in microcolumn separation techniques, more particularly in capillary electrophoresis (CE), where a sample is injected as a sample plug into a sampling device which comprises at least a channel for the electrolyte buffer and a supply and drain channel for the sample. The supply and drain channels discharge into the electolyte channel at respective supply and drain ports. The distance between the supply port and the drain port geometrically defines a sample volume. The injection of the sample plug into the electrolyte channel is accomplished electrokinetically by applying an electric field across the supply and drain channels for a time at least long enough that the sample component having the lowest electrophoretic mobility is contained within the geometrically defined volume.; The supply and drain channels each are inclined to the electrolyte channel. Means are provided for electrokinetically injecting the sample into the sample volume. The resistance to flow of the source and drain channels with respect to the electrolyte buffer is at least about 5% lower than the respective resistance to flow of the electrolyte channel.

Title
Method for controlling sample introduction in microcolumn separation techniques and sampling device.
Application Number
EP19930810272 19930415
Publication Number
0620432 (A1)
Application Date
April 15, 1993
Publication Date
October 19, 1994
Inventor
Effenhauser Carlo S Dr
CA
Harrison D Jed Prof Dr
CA
Manz Andreas Dr
CH
Assignee
Ciba Geigy
CH
IPC
G01N 27/447
G01N 37/00
G01N 27/447
G01N 01/10
G01N 01/00
G01N 37/00
G01N 27/447
G01N 01/10
G01N 01/00
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