0586238-A2 is referenced by 22 patents and cites 4 patents.

A method of producing sustained-release microcapsules containing a biologically active substance from an W/O emulsion comprising an inner aqueous phase containing said biologically active substance and an external oil phase containing a biodegradable polymer, characterized in that microcapsules formed on microencapsulation of said biologically active substance with said biodegradable polymer are heated at a temperature not lower than the glass transition temperature of said biodegradable polymer but not so high as to cause aggregation of the microcapsules. This method enables the production of very useful sustained release microcapsules adapted to release a bologically active substance at a calculated rate over a protracted time period starting immediately following administration without an initial burst within one day following administration.

Title
Method of producing sustained-release microcapsules.
Application Number
EP19930306908 19930901
Publication Number
0586238 (A2)
Application Date
September 1, 1993
Publication Date
March 9, 1994
Inventor
Yamada Minoru
JP
Ogawa Yasuaki Koaza Tanita
JP
Kamei Shigeru
JP
Assignee
Takeda Chemical
JP
IPC
A61K 09/52
A61K 09/16
A61K 09/50
B01J 13/02
A61K 38/21
A61K 38/08
A61K 38/06
A61K 09/52
A61K 09/16
B01J 13/02
A61K 38/21
A61K 38/09
A61K 38/06
A61K 09/52
A61K 09/16
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