0585913-A2 is referenced by 58 patents and cites 1 patents.

Novel compound represented by the formula: wherein ring A may be substituted; ring B represents an optionally substituted benzene ring; either X or Y represents -NR- (R represents a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted hydroxyl group or an optionally substituted amino group), -O- or -S-, the other representing -CO-, -CS- or -C(R)R- (R and R independently represent a hydrogen atom or an optionally substituted hydrocarbon group), or either X or Y represents -N=, the other representing =CR- (R represents a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group , an optionally substituted amino group, a substituted hydroxyl group or a mercapto group substituted by an optionally substituted hydrocarbon group); represents a single or double bond; when is a single bond, Z represents -CR- (R represents a hydrogen atom, hydroxyl group or an optionally substituted hydrocarbon group) or a nitrogen atom, or (ii) when is a double bond, Z represents a carbon atom; D represents a C1-3 alkylene group which may be substituted by an oxo group or a thioxo group, or D and Y, taken together, may form a 5- to 7-membered ring which may be substituted by an oxo group or a thioxo group; E represents -NR- (R represents a hydrogen atom or an optionally substituted hydrocarbon group), -O- or -S(O)n- (n is 0,1 or 2), or R and Y, taken together, may form a 5- to 7- membered ring which may be substituted by an oxo group or a thioxo group; G represents a bond or a C1-3 alkylene group; ; Ar represents an optionally substituted aryl group or an optionally substituted heterocyclic group, provided that (1) when (i) -X-Y- represents - O-CO- or -CO-O-, (ii) D represents -CO- and (iii) E represents -NR-, either (a) G represents a C1-3 alkylene group and Ar represents a substituted aryl group or a substituted heterocyclic group, or (b) G represents a bond and R represents an optionally substituted hydrocarbon group, and (2) when -X-Y- represents -NH-CO-, D represents -CO-, or a salt thereof having an excellent activity of inhibiting ACAT, lowering chlesterol in blood and inhibiting tachykinin recepter, or a salt thereof, their production and use.

Title
Condensed heterocyclic compounds, their production and use.
Application Number
EP19930114024 19930902
Publication Number
0585913 (A2)
Application Date
September 2, 1993
Publication Date
March 9, 1994
Inventor
Doi Takayuki
JP
Ishimaru Takenori
JP
Ikeda Hitoshi
JP
Natsugari Hideaki
JP
Assignee
Takeda Chemical
JP
IPC
C07D 471/04
C07D 311/76
C07D 311/18
C07D 217/26
C07D 215/54
C07D 215/22
A61K 31/47
A61K 31/37
C07D 217/24
C07D 471/00
C07D 409/00
C07D 401/00
C07D 311/00
C07D 241/00
C07D 217/00
C07D 215/00
C07D 471/04
C07D 409/06
C07D 401/06
C07D 311/76
C07D 311/18
C07D 241/52
C07D 217/26
C07D 217/24
C07D 215/54
C07D 215/227
C07D 215/18
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