0546676-A1 is referenced by 81 patents.

This invention relates to a composition comprising a tramadol material and a nonsteroidal antiinflammatory drug, and its use. The compositions are pharmacologically useful in treating pain and tussive conditions. The compositions are also subject to less opioid side-effects such as abuse liability, tolerance, constipation and respiratory depression. Furthermore, where the components of the compositions are within certain ratios the pharmacological effects of the compositions are superadditive (synergistic).

Title
Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug.
Application Number
EP19920309930 19921029
Publication Number
0546676 (A1)
Application Date
October 29, 1992
Publication Date
June 16, 1993
Inventor
Raffa Robert B
US
Assignee
Mcneilab
US
IPC
A61P 29/00
A61K 31/135
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A61K 31/405
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A61K 31/60
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A61K 31/13
A61P 29/00
A61P 25/04
A61K 45/06
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A61K 31/42
A61K 31/415
A61K 31/405
A61K 31/19
A61K 31/13
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