0543662-A2 is referenced by 35 patents and cites 5 patents.

Compounds of formula (I) : (in which: R is hydrogen, methyl or hydroxymethyl; R is substituted alkyl; R and R are each hydrogen, halogen, hydroxy, alkoxy, carboxy, alkoxycarbonyl, alkyl, nitro, haloalkyl, or substituted alkyl; X is oxygen atom or a sulphur; and Ar optionally substituted phenyl or naphthyl); and pharmaceutically acceptable salts thereof have a variety of valuable pharmaceutical activities, including anti-diabetic and anti-obesity activities; in addition, they are capable of treating or preventing hyperlipemia and hyperglycemia and, by inhibiting the action of aldose reductase, they can also be effective in the treatment and prevention of complications of diabetes.

Title
Aromatic amino-alcohol derivatives having anti-diabetic and anti-obesity properties, their preparation and their therapeutic uses.
Application Number
EP19920310625 19921120
Publication Number
0543662 (A2)
Application Date
November 20, 1992
Publication Date
May 26, 1993
Inventor
Yoshioka Shinji
JP
Horikoshi Hiroyoshi
JP
Yoshioka Takao
JP
Fujita Takashi
JP
Assignee
Sankyo Co
JP
IPC
C07D 277/34
C07C 259/06
C07C 217/22
C07C 217/18
A61K 31/13
C07D 277/00
C07C 323/00
C07C 259/00
C07C 235/00
C07C 217/00
A61P 03/00
A61K 31/135
A61K 31/13
C07C 215/00
C07D 277/34
C07D 277/20
C07C 323/62
C07C 323/25
C07C 259/06
C07C 235/34
C07C 217/22
C07C 217/18
C07C 215/68
A61P 03/10
A61P 03/06
A61P 03/04
A61K 31/135
A61K 31/13
C07C 215/08
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