0543310-A2 is referenced by 30 patents and cites 2 patents.

A prophylactic or therapeutic agent for malignant hypercalcemia, bone Paget's disease and osteoporosis is disclosed, which contains as an active ingredient a dipeptide derivative represented by formula: RNH-CH(R)-CO-NH-CH(R)-R (I> wherein R represents an aliphatic acyl group, a halogen-substituted aliphatic acyl group, or benzyloxycarbonyl group; R represents a lower alkyl group or an aralkyl group; R represents a lower alkyl group, an aralkyl group, or methylthioethyl group; R represents formyl group, an aliphatic acyl group, an aliphatic acyl group substituted with a halogen atom or a lower alkoxycarbonyl group, a di-lower alkoxymethyl group, a diacyloxymethyl group, a lower alkoxalyl group, a 1-hydroxy-2-lower alkoxycarbonylethyl group, a halogen-substituted 1-hydroxy-2-lower alkoxycarbonylethyl group, hydroxyiminomethyl group, ureidoiminomethyl group, benzimidazol-2-yl group, or a group: wherein A and B, which may be the same or different, each represents O, S, NH; and n represents 2 or 3; provided that R is not a formyl group when R is an n-butyl group.

Dipeptide derivative and prophylactic and therapeutic agent for bone diseases containing the same.
Application Number
EP19920119558 19921116
Publication Number
0543310 (A2)
Application Date
November 16, 1992
Publication Date
May 26, 1993
Hayashi Yasuhiro
Kiso Yoshinobu
Niwata Shinjiro
Saitoh Masayuki
Higuchi Naoki
C07C 271/20
A61K 31/415
A61K 31/27
C07D 339/00
C07D 327/00
C07D 317/00
C07D 277/00
C07D 235/00
C07C 323/00
C07C 281/00
C07C 271/00
C07C 251/00
C07C 237/00
A61P 19/00
A61P 03/00
C07D 339/08
C07D 339/06
C07D 327/04
C07D 317/28
C07D 277/04
C07D 235/14
C07C 323/41
C07C 281/10
C07C 271/22
C07C 251/38
C07C 237/22
C07C 237/12
A61P 43/00
A61P 19/10
A61P 03/14
A61P 03/02
A61K 38/00
A61K 31/357
A61K 31/335
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