0532979-A2 is referenced by 1 patents.

Peptides having antigenic or immunogenic determinants are proposed which are recognised by autoantibodies, in particular in body fluids of patients who suffer from systemic lupus erythematosus (SLE). The two peptides are preferably the C-terminus of H1 containing the sequence section 187 - 211 and the N-termini of H2B containing the sequence sections 1 - 35 and 36 - 76 which exhibit cross-reactions with the autoantibodies (anti-histone antibodies). The invention additionally indicates routes for the formation of monoclonal antibodies and anti-idiotypic antibodies which are directed against the autoantibodies. The diagnosis of SLE can be carried out according to the invention with increased safety and the monoclonal antibodies directed against the autoantibodies are also suitable for the preparation of means for the therapy of SLE.

Title
Peptides for the preparation of means for diagnosis and therapy of systemic lupus.
Application Number
EP19920114992 19920902
Publication Number
0532979 (A2)
Application Date
September 2, 1992
Publication Date
March 24, 1993
Inventor
Cebecauer Ladislav Dr
CS
Schoenberger Arno Dr
DE
Zeppezauer Michael Prof Dr
DE
Assignee
Symbiotec
DE
IPC
G01N 33/68
G01N 33/577
C12P 21/08
C07K 15/06
A61K 39/395
G01N 33/68
G01N 33/577
G01N 33/564
C12P 21/08
C12N 15/02
C07K 16/42
C07K 16/18
C07K 16/00
C07K 14/435
C07K 14/00
C07K 07/00
A61P 37/00
A61K 39/395
G01N 33/68
G01N 33/577
G01N 33/564
C12P 21/08
C12N 15/02
C07K 16/42
C07K 16/18
C07K 16/00
C07K 14/47
C07K 14/00
C07K 07/08
C07K 07/06
C07K 07/00
A61P 37/00
A61K 39/395
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