0502812-A1 is referenced by 48 patents and cites 3 patents.

The invention concerns recombinant antibodies directed to the extracellular domain of the human growth factor receptor c-erbB-2 comprising a light chain variable domain and a heavy chain variable domain of a monoclonal antibody, monoclonal antibodies directed to c-erbB-2 themselves, a method of manufacture of said recombinant antibodies and said monoclonal antibodies, hybridoma cells secreting said monoclonal antibodies, a method of manufacture of said hybridoma cells, DNA coding for the heavy chain variable domain, for the light chain variable domain and for the recombinant antibody, a method of manufacture of said DNA, hybrid vectors suitable for expression of said DNA, host cells transformed with said DNA, and the use of said recombinant antibodies and said monoclonal antibodies in the diagnosis and treatment of tumors.

Title
Recombinant antibodies specific for a growth factor receptor.
Application Number
EP19920810056 19920127
Publication Number
0502812 (A1)
Application Date
January 27, 1992
Publication Date
September 9, 1992
Inventor
Zwickl Markus
CH
Hardman Norman Dr
CH
Groner Bernd Dr
CH
Harwerth Ina Maria
DE
Hynes Nancy E Dr
CH
Wels Winfried Stephan Dr
CH
Assignee
Ciba Geigy
CH
IPC
C07K 16/18
C07K 01/00
G01N 33/577
G01N 33/574
G01N 33/566
G01N 33/53
C12P 21/08
C12N 15/62
C12N 15/55
C12N 15/13
C12N 15/09
C12N 15/06
C12N 15/02
C12N 05/20
C12N 05/18
C12N 05/10
C12N 01/21
C07K 19/00
C07K 16/32
C07K 16/30
C07K 16/28
C07K 16/00
C07K 01/22
A61P 35/00
A61K 47/48
A61K 39/395
A61B 10/00
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