0498680-A1 is referenced by 58 patents and cites 2 patents.

The compounds of the invention are beta -amino- alpha -hydroxycarboxylic acid derivatives having the formula (I): wherein: R represents a group of formula R(Z)xA- wherein R is hydrogen, or a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl or heterocyclic group or R is a group of formula -NRR wherein R and R are hydrogen atoms, alkyl groups, unsubstituted or substituted cycloalkyl, heterocyclic, aralkenyl or aryl groups, Z represents oxygen or sulphur; A represents a group of formula -CO-, -COCO-, -SO-, -SO2- or -CS-; and x is the cipher 0 or the integer 1; R represents a hydrogen atom, or a substituted or unsubstituted alkyl group; R is hydrogen, or a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl or heterocyclic group; ; R is a hydrogen atom, a substituted or unsubstituted alkyl, aryl or heterocyclic group; and R represents a group of formula -B-(CO)-Y-Rc_y , wherein B represents a heterocyclic group unsubstituted or substituted with at least one alkyl group; Y represents an oxygen atom, a nitrogen atom or a sulphur atom; y is the integer 1 when Y represents an oxygen atom or a sulphur atom, and 2 when Y represents a nitrogen atom; and R represents is hydrogen, or a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl or heterocyclic group; and, where there are two groups or atoms represented by R, they are the same or different; and and pharmaceutically acceptable salts and esters thereof.

Title
New beta-amino-alpha-hydroxycarboxylic acids and their use.
Application Number
EP19920301100 19920210
Publication Number
0498680 (A1)
Application Date
February 10, 1992
Publication Date
August 12, 1992
Inventor
Handa Hiroshi
JP
Nishigaki Takashi
JP
Komai Tomoaki
JP
Higashida Susumu
JP
Sakurai Mitsuya
JP
Yabe Yuichiro
JP
Assignee
Sankyo Co
JP
IPC
C07K 05/06
C07D 417/12
C07D 413/12
C07D 409/12
C07D 405/12
C07D 403/12
C07D 401/12
C07D 217/26
C07D 207/16
A61K 31/40
C07K 05/00
C07D 417/00
C07D 409/00
C07D 405/00
C07D 403/00
C07D 401/00
C07D 239/00
C07D 207/00
A61K 38/05
C07K 05/02
C07D 417/12
C07D 409/12
C07D 405/12
C07D 403/12
C07D 401/12
C07D 239/72
C07D 207/16
A61K 38/05
C07K 05/072
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