0451216-A1 is referenced by 153 patents and cites 1 patents.

Novel methods for designing humanized immunoglobulins having one or more complementary determining regions (CDR's) from a donor immunoglobulin and a framework region from a human immunoglobulin comprising first comparing the framework or variable region amino acid sequence of the donor immunoglobulin to corresponding sequences in a collection of human immunoglobulin chains, and selecting as the human immunoglobulin one of the more homologous sequences from the collection. Each humanized immunoglobulin chain may comprise about 3 or more amino acids from the donor immunoglobulin in addition to the CDR's, usually at least one of which is immediately adjacent to a CDR in the donor immunoglobulin. The heavy and light chains may each be designed by using any one or all three additional position criteria.; When combined into an intact antibody, the humanized immunoglobulins of the present invention will be substantially non-immunogenic in humans and retain substantially the same affinity as the donor immunoglobulin to the antigen, such as a protein or other compound containing an epitope.

Title
Chimeric immunoglobulins specific for p55 tac protein of the il-2 receptor.
Application Number
EP19900903576 19891228
Publication Number
0451216 (A1)
Application Date
December 28, 1989
Publication Date
October 16, 1991
Inventor
Selick Harold Edwin
US
Queen Cary L
US
Assignee
Protein Design Labs
US
IPC
C12N 15/13
C07K 01/00
A61P 21/00
A61P 19/00
A61P 03/00
C12P 21/08
C12P 21/00
C12N 15/00
C12N 07/01
C12N 05/10
C12N 01/21
C12N 01/19
C12N 01/15
C07K 19/00
C07K 16/46
C07K 16/28
C07K 16/24
C07K 16/18
C07K 16/08
C07K 16/00
C07K 14/715
C07K 14/705
C07K 14/435
C07K 01/22
A61P 37/06
A61P 37/00
A61P 29/00
A61P 25/00
A61P 21/04
A61P 19/02
A61P 03/10
A61K 39/395
C12N 15/09
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