0420237-A1 is referenced by 67 patents and cites 3 patents.

The biphenylmethane derivative having the formula (I) is disclosed in which R1 is hydrogen, an alkyl, a cycloalkyl, a halogenated alkyl, -S-R7, -SO2-R7, -C IDENTICAL C-R7 or -(CH2)p-OR7, R7 being hydrogen, an alkyl, a cycloalkyl or a halogenated alkyl, p being zero or 1, -A1=A2-A3=A4- is -CH=CH-CH=CH-, -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH-, -CH=CH-CH=N- or -CH=N-CH=N-, R2 and R3 are each hydrogen, a halogen, a lower alkyl, a lower alkoxy, a carbamoyl or cyano, R4 is hydrogen or a lower alkyl, R5 is 1H-tetrazol-5-yl, carboxyl (-COOH) or a carboxylic ester and R6 is hydrogen, a halogen, hydroxyl or a lower alkoxy, or a pharmacologically acceptable salt thereof. Further, pharmaceutical compositions containing the same and the use of the biphenylmethane derivative for the preparation of such compositions for preventing and treating hypertension and/or cardiac failure are disclosed.

Title
Biphenylmethane derivative, the use of it and pharmacological compositions containing same.
Application Number
EP19900118565 19900927
Publication Number
0420237(A1)
Application Date
September 27, 1990
Publication Date
April 3, 1991
Inventor
Minami Norio
JP
Hamano Sachiyuki
JP
Matsuoka Toshiyuki
JP
Musha Takashi
JP
Ishihara Hiroki
JP
Mori Nobuyuki
JP
Hiroshima Osamu
JP
Yoneda Naoki
JP
Matsukura Masayuki
JP
Miyake Kazutoshi
JP
Assignee
Eisai
JP
IPC
C07D 487/00
C07D 471/00
C07D 403/00
C07D 235/00
A61K 31/4164
C07D 487/04
C07D 471/04
C07D 403/10
C07D 235/28
C07D 235/26
C07D 235/12
C07D 235/10
C07D 235/06
A61P 43/00
A61P 09/12
A61P 09/00
A61K 31/505
A61K 31/496
A61K 31/44
A61K 31/435
A61K 31/4184
A61K 31/415
A61K 31/00
C07D 235/08
View Original Source Download PDF