In an acoustic wave therapy apparatus, a holder (100) is provided with an irradiation device for generating acoustic waves for medical treatment, and a bag (10) having a variable size and containing an acoustic wave propagation medium. The holder is also provided with a probe rod (30) having at its one end an ultrasonic probe for ultrasonic tomographic imaging. The probe rod has at least one opening (32, 34) at its one end. A pipe (40, 42) is connected to the opening of the probe rod. The pipe is connected to fluid equipment (400) for supplying/discharging the acoustic wave propagation medium into/from the bag member. The holder is held by a hand-type holding apparatus. A connector for connecting/disconnecting the pipe is arranged on a C-arm included in the hand-type holding apparatus.