0389898-A2 is referenced by 139 patents and cites 2 patents.

The compounds of the formula in which A, R, R, R and R have the meaning stated in Claim 1, in the form of optically pure diastereomers, mixtures of diastereomers, diastereomeric racemates or mixtures of diastereomeric racemates, and pharmaceutically utilisable salts thereof, inhibit the action of the natural enzyme renin and can accordingly be used in the form of pharmaceutical products for controlling or preventing high blood pressure and heart failure. They can be prepared by various processes known per se.

Title
Peptide derivatives of amino acids having a renin-inhibiting effect.
Application Number
EP19900105051 19900317
Publication Number
0389898 (A2)
Application Date
March 17, 1990
Publication Date
October 3, 1990
Inventor
Wostl Wolfgang Dr
DE
Ramuz Henri Prof Dr
CH
Neidhart Werner Dr
DE
Maerki Hans Peter Dr
CH
Branca Quirico Dr
CH
Assignee
Hoffmann La Roche
CH
IPC
C07D 401/00
C07D 333/00
C07D 277/00
C07D 233/00
C07D 231/00
C07C 271/00
C07C 237/00
A61K 31/21
C07K 05/065
C07K 05/02
C07D 403/12
C07D 401/12
C07D 333/24
C07D 277/30
C07D 277/20
C07D 233/64
C07D 233/54
C07D 231/12
C07C 271/20
C07C 271/18
C07C 271/16
C07C 237/06
A61P 09/12
A61P 09/00
A61K 38/55
A61K 31/445
A61K 31/4427
A61K 31/426
A61K 31/425
A61K 31/415
A61K 31/381
A61K 31/38
A61K 31/27
A61K 31/16
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