0347146-A2 is referenced by 101 patents and cites 2 patents.

Compounds of the formula (1) : or pharmaceutically acceptable salts thereof as described, wherein is a pyridine, pyrazine or triazine ring; R is C1-6alkyl, C2-6alkenyl, C3-5cycloalkylC1-6alkyl, or C1-6alkyl substituted by 1 to 6 fluoro groups; R is C1-6alkylthio, C1-6alkylsulphonyl, C1-6alkoxy, hydroxy, hydrogen, hydrazino, C1-6alkyl, phenyl, -NHCOR wherein R is hydrogen or C1-6alkyl, or -NRR, wherein R and R together with the nitrogen atom to which they are attached form a pyrrolidino, piperidino, hexahydroazepino, morpholino or piperazino ring, or R and R are independently hydrogen, C3-5cycloalkyl or C1-6alkyl which is optionally substituted by -CF3, phenyl, -S(O)nC1-6alkyl wherein n is 0, 1 or 2, -OR, -CO2R or -NRR wherein R to R are independently hydrogen or C1-6alkyl, provided that the carbon atom adjacent to the nitrogen atom is not substituted by said -S(O)nC1-6alkyl, -OR or -NRR groups; and when is a pyrazine ring it may be further substituted by hydroxy when R is hydroxy. Their use as medicaments, pharmaceutical compositions comprising them and processes for their preparation are also described.

Fused pyrimidine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them.
Application Number
EP19890305911 19890612
Publication Number
0347146 (A2)
Application Date
June 12, 1989
Publication Date
December 20, 1989
Rawlings Derek Anthony
Flynn Seyn Thomas
Coates William John
Smith Kline French Lab
C07D 487/00
C07D 475/00
C07D 471/00
C07D 253/00
C07D 241/00
C07D 213/00
A61P 37/00
A61P 11/00
A61P 09/00
C07D 487/04
C07D 475/02
C07D 471/04
C07D 253/07
C07D 253/06
C07D 241/26
C07D 241/24
C07D 241/10
C07D 213/82
C07D 213/81
A61P 37/08
A61P 11/08
A61P 09/08
A61K 31/53
A61K 31/519
A61K 31/505
View Original Source Download PDF