0346847-A2 is referenced by 262 patents and cites 2 patents.

Compounds of the formula wherein R represents alkoxycarbonyl, aralkoxycarbonyl, alkanoyl, cycloalkylcarbonyl, aralkanoyl, aroyl, heterocyclylcarbonyl, alkylsulphonyl, arylsulphonyl, monoaralkylcarbamoyl, cinnamoyl or alpha -aralkoxycarbonylaminoalkanoyl and R represents hydrogen or R and R together with the nitrogen atom to which they are attached represent a cyclic imide group of the formula in which P and Q together represent an aromatic system; R represents alkyl, cycloalkyl, aryl, aralkyl, heterocyclylalkyl, cyanoalkyl, alkylsulphinylalkyl, carbamoylalkyl or alkoxycarbonylalkyl or, when n stands for zero, R can also represent alkylthioalkyl or, when n stands for 1, R can also represent alkylsulphonylalkyl; R represents alkyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl; R represents hydrogen and R represents hydroxy or R and R together represent oxo; R and R together represent a trimethylene or tetramethylene group which is optionally substituted by hydroxy, alkoxycarbonylamino or acylamino or in which one -CH2- group is replaced by -NH-, -N(alkoxycarbonyl)-, -N(acyl)- or -S- or which carries a fused cycloalkane, aromatic or heteroaromatic ring; and R represents alkoxycarbonyl, monoalkylcarbamoyl, monoaralkylcarbamoyl, monoarylcarbamoyl or a group of the formula in which R and R each represent alkyl; and their pharmaceutically acceptable acid addition salts inhibit proteases of viral origin and can be used as medicaments for the treatment or prophylaxis of viral infections. They can be manufactured according to generally known procedures.

Title
Amino acid derivatives.
Application Number
EP19890110717 19890613
Publication Number
0346847 (A2)
Application Date
June 13, 1989
Publication Date
December 20, 1989
Inventor
Thomas Gareth John
Redshaw Sally
Martin Joseph Armstrong
Machin Peter James
Handa Balraj Krishan
Assignee
Hoffmann La Roche
CH
IPC
C07D 241/04
C07D 217/26
C07D 215/48
C07D 211/60
C07D 209/52
C07D 209/48
C07D 209/42
C07D 207/16
C07C 323/60
C07C 317/48
C07C 311/18
C07C 311/05
C07C 291/02
C07C 237/22
C07C 237/10
A61P 43/00
A61P 31/12
A61K 38/00
A61K 31/495
A61K 31/472
A61K 31/47
A61K 31/445
A61K 31/4427
A61K 31/435
A61K 31/426
A61K 31/425
A61K 31/404
A61K 31/4035
A61K 31/403
A61K 31/401
A61K 31/40
A61K 31/33
A61K 31/13
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