0337714-A2 is referenced by 242 patents and cites 1 patents.

Compounds of the form A-G-B-B-J wherein A is an amine protecting group commonly employed in peptide synthesis, G a dipeptide isostere, B an amino acid or analog thereof, and J a small terminal group are described. These compounds are useful in the inhibition of HIV protease, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

Hiv protease inhibitors useful for the treatment of aids.
Application Number
EP19890303539 19890411
Publication Number
0337714 (A2)
Application Date
April 11, 1989
Publication Date
October 18, 1989
Ghosh Arun K
Graham Samuel L
Lyle Terry A
Thompson Wayne J
Desolms S Jane
Young Steven D
Vacca Joseph P
Darke Paul L
Huff Joel R
Sigal Irving S
Merck & Co
C07C 229/46
C07C 229/38
C07C 229/26
C07C 229/22
C07C 229/12
A61P 43/00
A61P 37/04
A61P 31/18
A61P 31/12
A61K 38/00
A61K 31/66
A61K 31/5377
A61K 31/5375
A61K 31/535
A61K 31/496
A61K 31/495
A61K 31/47
A61K 31/4427
A61K 31/4418
A61K 31/4409
A61K 31/4406
A61K 31/4402
A61K 31/44
A61K 31/421
A61K 31/42
A61K 31/415
A61K 31/352
A61K 31/35
A61K 31/33
A61K 31/275
A61K 31/27
A61K 31/195
A61K 31/16
C12N 09/99
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