0329348-A2 is referenced by 49 patents and cites 2 patents.

2 min ,3 min -Dideoxy-2 min ,2 min -difluoronucleosides are useful for treating susceptible neoplasms and viral infections in mammals and have the formula wherein: R is hydrogen, C1-C4 alkyl or - @-R; R is a base defined by one of the formulae R is hydrogen, amino, azido or fluoro; R is hydrogen or fluoro; each R independently is hydrogen or C1-C4 alkyl; R is hydrogen, C1-C4 alkyl or - @-R; R is hydrogen, C1-C4 alkyl, C1-C4 haloalkyl, amino, bromo, fluoro, chloro or iodo; R is hydroxy or amino; R is hydrogen, bromo, chloro or iodo; R is -NHR, bromo, chloro, hydroxy, fluoro or iodo; Z is N or C-R; or a pharmaceutically-acceptable salt thereof; with the proviso that when R is fluoro, R is other than amino or azido.

Title
2,3-dideoxy-2,2-difluoronucleosides.
Application Number
EP19890301309 19890210
Publication Number
0329348 (A2)
Application Date
February 10, 1989
Publication Date
August 23, 1989
Inventor
Kroin Julian Stanley
Grossman Cora Sue
Hertel Larry Wayne
Assignee
Lilly Co Eli
US
IPC
C07H 19/167
C07H 19/067
C07H 05/04
C07H 05/02
A61K 31/70
C07H 19/00
C07H 05/00
A61P 35/00
A61P 31/00
A61K 31/7042
A61K 31/70
C07H 19/16
C07H 19/12
C07H 19/06
C07H 19/04
C07H 05/02
A61P 35/00
A61P 31/12
A61K 31/708
A61K 31/7076
A61K 31/7072
A61K 31/7068
A61K 31/7064
A61K 31/706
A61K 31/7056
A61K 31/7052
A61K 31/7042
A61K 31/70
C07H 19/056
View Original Source Download PDF