0324938-A1 is referenced by 198 patents and cites 1 patents.

A microbubble-type ultrasonic imaging agent is provided comprising a parenterally-administerable aqueous medium containing a dispersion of microspheres predominantly of diameters less than 10 microns, wherein the microspheres consist of gas microbubbles encapsulated with water-insolubilized biocompatible material. The imaging agent is characterized by having a concentration of greater than 100 x 10 microspheres per milliliter, and a stability such that this concentration is maintained for over 4 weeks at a temperature of 20 to 25 DEG C. A preferred method of producing the imaging agent is also disclosed.

Title
Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production.
Application Number
EP19880120371 19881206
Publication Number
0324938 (A1)
Application Date
December 6, 1988
Publication Date
July 26, 1989
Inventor
Westkaemper Peter J
Widder Kenneth J
Assignee
Molecular Biosystems
US
IPC
G01N 29/04
A61K 49/00
A61K 09/50
A61K 49/22
A61B 08/00
A61K 49/22
A61B 08/00
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