0322240-A2 is referenced by 44 patents.

Chimeric hosts are provided by introducing into an immunocompromised mammalian host xenogeneic, usually human, tissue under conditions where the xenogeneic tissue may both grow and interact, in such a way that undifferentiated ("stem") cells may be observed to differentiate and to proliferate. For example, tissues from hematopoietic organs are employed where tissue from different organs may be used which allow for differentiation and proliferation of the xenogeneic hematopoietic stem cells. Into SCID mice may be introduced fetal tissue, fetal liver tissue providing stem cells, thymus tissue, where the thymus grows into a competent thymus organ, and lymph node tissue, where the lymph node tissue grows into a competent lymph node, and the stem cells are processed to produce functional human B- and T-cells.

Title
Chimeric immunocompromised mammals and their use.
Application Number
EP19880312222 19881222
Publication Number
0322240 (A2)
Application Date
December 22, 1988
Publication Date
June 28, 1989
Inventor
Mccune Joseph Mccrary
Assignee
Univ Leland Stanford Junior
US
IPC
C12P 21/00
C12N 15/00
G01N 33/569
C07K 16/18
C07K 16/00
A61K 35/12
A01K 67/027
G01N 33/569
C07K 16/18
C07K 16/00
A61K 35/12
A01K 67/027
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