0315456-A2 is referenced by 81 patents and cites 2 patents.

There is provided a substantially monomeric immunoreactive composition of lowered immunogenic potential, said substance comprising an immunoglobulin, or immunoglobulin fragment, covalently linked to a low molecular weight polysaccharide derivative, preferably an oxidized dextran. Such immunoreactive compositions retain, compared to the free immunoglobulin or fragment, substantially unaltered immunoreactivity, localization properties, and substantially unaltered or improved pharmacokinetic properties.

Title
Polysaccharide-modified immunoglobulins having reduced immunogenic potential or improved pharmacokinetics.
Application Number
EP19880310372 19881103
Publication Number
0315456 (A2)
Application Date
November 3, 1988
Publication Date
May 10, 1989
Inventor
Fagnani Roberto Cesare
Assignee
Hybritech
US
IPC
C12N 15/00
A61K 39/44
G01N 33/563
G01N 33/531
C12P 21/08
C12N 15/02
C07K 19/00
C07K 16/00
C07K 14/00
A61P 35/00
A61K 45/00
A61K 39/44
A61K 39/395
G01N 33/563
G01N 33/531
C12P 21/08
C12N 15/02
C07K 19/00
C07K 16/00
C07K 14/00
A61P 35/00
A61K 45/00
A61K 39/44
A61K 39/395
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