Polysaccharide-modified immunoglobulins having reduced immunogenic potential or improved pharmacokinetics.
EPO Patent 0315456-A2
0315456-A2 is referenced by 81 patents and cites 2 patents.
There is provided a substantially monomeric immunoreactive composition of lowered immunogenic potential, said substance comprising an immunoglobulin, or immunoglobulin fragment, covalently linked to a low molecular weight polysaccharide derivative, preferably an oxidized dextran. Such immunoreactive compositions retain, compared to the free immunoglobulin or fragment, substantially unaltered immunoreactivity, localization properties, and substantially unaltered or improved pharmacokinetic properties.
