0315071-A2 is referenced by 101 patents and cites 3 patents.

Compounds of the general formula in which R denotes hydroxyl, lower alkoxy, amino, mono- or di-lower alkylamino; R denotes hydrogen, alkyl, alkoxy or halogen; R, R, R, R, R and R independently of one another denote hydrogen or lower alkyl; R and R together denote a methylene or hydroxymethylene group; R, R, R and R denote hydrogen or lower alkyl; or R and R together denote an oxo group or spirocyclo-lower alkyl; or R denotes hydrogen and R denotes hydroxyl or acetoxy; and one of the radicals R and R denotes hydrogen and the other denotes lower alkyl or trifluoromethyl, and physiologically tolerable salts of carboxylic acids of the formula I can be used as medicines, in particular for the treatment of neoplasias, acne and psoriasis.; The novel compounds can be prepared by synthesis of the C(R)=C(R) double bond according to Wittig from an appropriate bicyclic and an appropriate monocyclic component and, if appropriate, subsequent modification of functional groups.

Title
Benzocyclohepten derivatives, their preparation and utilisation for pharmaceutics.
Application Number
EP19880118011 19881028
Publication Number
0315071 (A2)
Application Date
October 28, 1988
Publication Date
May 10, 1989
Inventor
Mohr Peter Dr
Klaus Michael Dr
Assignee
Hoffmann La Roche
CH
IPC
C07C 235/44
C07C 235/42
C07C 233/65
C07C 233/61
C07C 231/00
C07C 69/94
C07C 67/00
C07C 65/38
C07C 65/19
C07C 63/74
C07C 63/66
C07C 51/353
C07C 51/00
C07C 49/792
C07C 49/697
C07C 49/67
C07C 47/457
C07C 45/68
C07C 45/61
C07C 45/51
C07C 45/46
C07C 33/16
C07C 15/24
C07C 13/39
A61P 37/08
A61P 35/00
A61P 29/00
A61P 17/00
A61P 03/06
A61K 31/235
A61K 31/215
A61K 31/19
A61K 31/165
A61K 31/015
C07C 69/76
View Original Source Download PDF