0313328-A1 is referenced by 18 patents and cites 3 patents.

A granular sustained-release formulation of a pharmacologically active substance presented in the form of a tablet, said tablet comprising sufficient granules to provide a predetermined dose or number of doses of the pharmacologically active substance and effervescent or water-dispersible ingredients, each of said granules having a diameter of preferably between 0.5 and 2.5 mm and comprising: a) a core comprising one or more pharmacologically active substances with preferably one or more excipients; and b) a coating covering substantially the whole surface of the core and comprising 100 parts of a water insoluble but water swellable acrylic polymer and from 20 to 70 parts of a water soluble hydroxylated cellulose derivative, the weight of the coating being from 2 to 25% of the weight of the core.; A method for preparing this effervescent or water-dispersible tablet formulation is also provided. Such formulations enable large dosages in sustained-release form to be more easily administered to patients.

Title
Sustained-release formulations.
Application Number
EP19880309802 19881019
Publication Number
0313328 (A1)
Application Date
October 19, 1988
Publication Date
April 26, 1989
Inventor
York Peter
Mulley Bryan Arthur
Barry Brian William
Assignee
Aps Res
GB
IPC
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