0268281-A2 is referenced by 8 patents and cites 2 patents.

A novel pyrrolidineamide derivative that exhibits inhibitory activity toward prolyl endopeptidase and its use as an inhibitor against said enzyme are provided. The pyrrolidineamide of the invention has the following general formula: wherein R is benzyloxycarbonyl or a group of the formula: (wherein m is an integer of from 1 to 5) and R is hydroxy, acyloxy or a group of the formula: (wherein R and R independently are a hydrogen atom, a halogen atom, a lower alkyl or a lower alkoxy). Pharmaceutical compositions comprising such derivatives are also provided together with processes for the production of the derivatives. The use of the derivatives for the manufacture of medicaments of therapeutic value is also provided.

Pyrrolidineamide derivative having anti-prolyl endopeptidase activity, compositions comprising the same, processes for the preparation of the same, and the use of the same for the preparation of a medicament of therapeutic value.
Application Number
EP19870117003 19871117
Publication Number
0268281 (A2)
Application Date
November 17, 1987
Publication Date
May 25, 1988
Fukami Harukazu
Hashimoto Masaki
Higuchi Naoki
Tanaka Takaharu
Saitoh Masayuki
C07D 207/16
A61K 31/40
C12N 09/99
C07D 207/00
A61P 43/00
A61P 25/00
A61K 31/401
A61K 31/40
C12N 09/99
C07D 207/16
A61P 43/00
A61P 25/28
A61K 31/401
A61K 31/40
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