0253412-A2 is referenced by 47 patents and cites 4 patents.

This invention relates to new nucleotide analogues exhibiting antiviral activity which represent N-(2-phosphonylmethoxyethyl) and N-(3-hydroxy-2-phosphonylmethoxypropyl) derivatives of pyrimidine and purine bases and to methods for their preparation and to their use in pharmaceutical compositions. These compounds are easily accessible from heterocyclic bases and their N-(2-hydroxyethyl) or N-(2,3-dihydroxypropyl) derivatives. Some of the compounds according to this invention exhibit a marked antiviral activity or can be converted into such active compounds by chemical transformations.

N-phosphonylmethoxyalkyl derivatives of pyrimidine and purine bases, methods for their preparation and pharmaceutical compositions therefrom with antiviral activity.
Application Number
EP19870110399 19870717
Publication Number
0253412 (A2)
Application Date
July 17, 1987
Publication Date
January 20, 1988
de Clercq Erik Prof Dr
Rosenberg Ivan
Holy Antonin Rndr
Rega Foundation
Ceskoslovenska Akademie Ved
C07F 09/65
A61K 31/675
C07F 09/00
A61P 31/00
A61K 31/675
A61K 31/66
C07F 09/6561
C07F 09/6512
A61P 31/12
A61K 31/675
A61K 31/66
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