0212489-A2 is referenced by 154 patents and cites 2 patents.

A modulator material is disclosed which has been isolated from macrophage cells that have been incubated with a stimulator material from an invasive stimulus. The modulator material comprises a protein that exhibits the ability to substantially completely suppress the activity of the anabolic enzyme lipoprotein lipase, prevent the differentiation of fat cells, increase the uptake of glucose in muscle cells, and raise antibodies to itself that are effective to protect a host against endotoxin-induced shock. The modulator material demonstrably lacks leucocyte activator activity, and in this latter characteristic distinguishes the known factors identified as Interleukin 1. A particular modulator material has been isolated and has been found to possess a molecular weight of about 17,000 daltons and a pl of 4.7-4.8.; Numerous diagnostic and therapeutic utilities are proposed, and testing procedures, materials in kit form and pharmaceutical compositions are likewise set forth.

Title
Anabolic activity modulator and uses thereof.
Application Number
EP19860110967 19860808
Publication Number
0212489 (A2)
Application Date
August 8, 1986
Publication Date
March 4, 1987
Inventor
Kawakami Masanobu
JP
Cerami Anthony
US
Assignee
Univ Rockefeller
US
IPC
A61K 37/02
A01K 67/00
A61P 03/00
C12Q 01/54
C12Q 01/44
C12Q 01/37
C12Q 01/34
C12Q 01/28
C12Q 01/02
C12Q 01/00
C12P 21/02
C12N 15/09
C12N 15/00
C12N 09/99
C07K 19/00
C07K 16/24
C07K 16/18
C07K 16/00
C07K 14/81
C07K 14/525
C07K 14/47
C07K 14/435
C07K 14/195
C07K 14/005
C07K 14/00
A61P 43/00
A61P 35/00
A61P 09/00
A61P 03/04
A61K 39/395
A61K 39/00
A61K 38/55
A61K 38/16
A61K 38/00
A61K 35/12
G01N 33/53
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