0209707-A2 is referenced by 29 patents and cites 16 patents.

2-Arylimidazoles of the formula in which R denotes a hydrogen atom or an alkyl group, Ar denotes a group of the formula A and B together with the two carbon atoms in between denote a group of the formula in which R1 denotes an alkylsulphenyl, alkylsulphinyl, alkylsulphonyl or alkylsulphoximino group, an alkylsulphoximino group substituted on the nitrogen atom by an alkanoyl, alkylsulphonyl or hydroxycarbonyl- alkylenecarbonyl group, an ethoxy or n-propoxy group which is in each case terminally substituted by an alkylsulphenyl, alkylsulphinyl, alkylsulphonyl or alkylsulphoximino group, an alkoxycarbonylamino or N-alkylaminocarbonylamino group, or also in the 4-position, a hydroxyl, phenylalkoxy, aminosulphonyl, alkylsulphonyloxy or alkylsulphonylamino group, R2 denotes a hydrogen atom or an alkoxy group,; R3 denotes an ethoxy or n-propoxy group which is in each case terminally substituted by an alkylsulphenyl, alkylsulphinyl, alkylsulphonyl or alkylsulphoximino group, R4 denotes an alkyl, alkoxycarbonyl, alkanoyl, N-alkanoylaminomethyl, benzoyl, phenylmethoxymethyl, aminocarbonyl, cyano, trifluoromethyl, aminosulphonyl, N-alkylaminocarbonylamino or N-alkyl- N-alkylaminocarbonylamino group, R5 denotes a hydrogen or halogen atom or an alkyl or cyano group and R6 denotes a hydrogen atom or an amino group, and the compounds 5-cyano-2-(4'-methanesulphonylamino-2'-methoxyphenyl)- benzimidazole, 4-methyl-2-(4'-methanesulphonyloxy-2'-methoxyphenyl)- benzimidazole, 4-cyano-2-(4'-methanesulphonyloxy-2'-methoxyphenyl)-benzimdazole, 4-aminocarbonyl-2-(4'-methanesulphonyloxy-2'-methoxyphenyl)- benzimidazole and 4-methoxycarbonyl-2-(4'-methanesulphonyloxy-2'-methoxyphenyl)- benzimidazole,; and their tautomers, if R represents a hydrogen atom, and their acid addition salts. The compounds and their physiologically tolerated acid addition salts have useful pharmacological properties, in particular an effect on the blood pressure and on the contractility of the heart muscle as well as antithrombotic effects and can be prepared by processes known per se.

Title
2-aryl imidazoles, pharmaceutical compositions containing them and process for their preparation.
Application Number
EP19860107969 19860611
Publication Number
0209707 (A2)
Application Date
June 11, 1986
Publication Date
January 28, 1987
Inventor
Diederen Willi Dr
DE
Van Meel Jacques Dr
DE
Bomhard Andreas Dr Dipl Chem
DE
Psiorz Manfred Dr Dipl Chem
DE
Heider Joachim Dr Dipl Chem
DE
Narr Berthold Dr Dipl Chem
DE
Noll Klaus Dr Dipl Chem
DE
Hauel Norbert Dr Dipl Chem
DE
Mueller Erich Dr Dipl Chem
DE
Assignee
Thomae Dr K
DE
IPC
C07D 473/32
C07D 473/08
C07D 473/00
C07D 471/04
C07D 235/02
A61K 31/52
A61K 31/495
A61K 31/415
C07D 235/18
C07D 473/00
C07D 471/00
C07D 235/00
A61P 09/00
A61P 07/00
A61K 31/505
A61K 31/496
A61K 31/435
A61K 31/4164
A61K 31/415
C07D 473/32
C07D 473/08
C07D 473/00
C07D 471/04
C07D 235/18
C07D 235/02
A61P 09/10
A61P 09/04
A61P 07/02
A61K 31/505
A61K 31/496
A61K 31/435
A61K 31/4184
A61K 31/415
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