0173494-A2 is referenced by 394 patents and cites 3 patents.

Chimeric multi-subunit receptors are provided involving a binding region resulting from the organization of two subunit chains and a non-binding region which may have physiological significance. Particularly, chimeric immunoglobulins are provided having variable regions from one species and constant regions from another species, by linking DNA sequences encoding for the variable regions of the light and heavy chains from one species to the constant regions of the light and heavy chains respectively from a different species. Introduction of the resulting genes into mammalian host cells under conditions for expressions provides for production of chimeric immunoglobulins having the specificity of the variable region derived from a first species and the physiological functions of the constant region from a different species.

Title
Chimeric receptors by dna splicing and expression.
Application Number
EP19850305604 19850807
Publication Number
0173494 (A2)
Application Date
August 7, 1985
Publication Date
March 5, 1986
Inventor
Oi Vernon T
US
Herzenberg Leonard A
US
Morrison Sherie L
US
Assignee
Univ Leland Stanford Junior
US
IPC
C12P 21/00
C12N 05/00
C07K 15/00
C12N 15/00
C12P 21/08
C12N 05/10
C07K 19/00
C07K 16/46
C07K 16/00
C07K 14/435
C07K 14/00
A61K 39/395
A61K 38/00
C12N 15/09
C12P 21/08
C12N 05/10
C07K 19/00
C07K 16/46
C07K 16/00
C07K 14/705
C07K 14/00
A61K 39/395
A61K 38/00
C12N 15/09
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