0154316-A2 is referenced by 337 patents and cites 3 patents.

The invention provides chemically modified lymphokines having R &lparstr& O-CH2CH2 &rparstr& n wherein R is a protective group for the terminal oxygen and n is an optional positive integer, bonded directly to at least one primary amino group of the lymphokine moiety, and a method of producing the same. The chemically modified lymphokines according to the invention can be produced by reacting a lymphokine with an aldehyde of the formula R &lparstr& O-CH2CH@ &rparstr& @-1O-CH2CHO wherein R and n are as defined above, in the presence of a reducing agent. The chemically modified lymphokines according to the invention are useful as drugs, among others.

Title
Chemically modified lymphokine and production thereof.
Application Number
EP19850102376 19850302
Publication Number
0154316 (A2)
Application Date
March 2, 1985
Publication Date
September 11, 1985
Inventor
Fujino Masahiko
Nishimura Osamu
Assignee
Takeda Chemical
JP
IPC
C07K 15/26
C07K 15/00
C12P 21/00
C12N 15/00
A61K 45/02
A61K 37/02
C07K 14/435
C07K 01/00
C07K 14/57
C07K 14/56
C07K 14/55
C07K 01/107
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