0126587-A1 is referenced by 87 patents and cites 4 patents.

Penem compounds are of the formule: where R1 is H or hydroxyethyl, wherein the -OH may be protected R2 is H or a protective group, e.g. alkoxycarbonyl; R3 is H or a protective group, e.g. alkyl; X is methylene or alkyl-methylene or S; Y is amino (-NH2) which may be substituted by various groups which can form a ring. Synthesis is from a B-lactam derivative wherein the 2-position has a reactive ester alcohol group or alkylsulfinyl group, reacted with a pyrrolidinyl derivative in a solvent in presence of a base. The compounds are useful as antimicrobial agents.

Title
Carboxylic thio-pyrrolidinyl beta-lactam compounds and production thereof.
Application Number
EP19840303128 19840509
Publication Number
0126587(A1)
Application Date
May 9, 1984
Publication Date
November 28, 1984
Inventor
Kato Masuhiro Sumitomo Chemica
Fukasawa Masatomo Sumitomo Che
Inoue Takaaki Sumitomo Chemica
Matsumura Haruki Sumitomo Chem
Sunagawa Makoto Sumitomo Chemi
Assignee
Sumitomo Chemical Co
JP
IPC
C07F 09/65
C07F 07/18
C07D 499/00
C07D 487/04
C07D 401/12
C07D 207/24
C07D 207/16
C07D 205/08
A61K 31/43
A61K 31/40
C07F 09/00
C07F 07/00
C07D 499/00
C07D 487/00
C07D 477/00
C07D 401/00
C07D 207/00
C07D 205/00
A61K 31/429
C07F 09/6561
C07F 07/18
C07F 07/10
C07D 499/887
C07D 499/88
C07D 499/32
C07D 499/00
C07D 487/04
C07D 477/20
C07D 401/12
C07D 207/24
C07D 207/16
C07D 205/08
A61K 31/43
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