0120694-A2 is referenced by 274 patents and cites 3 patents.

This invention relates to multichain polypeptides or proteins and processes for their production in cells of host organisms which have been transformed by recombinant DNA techniques. According to a first aspect of the present invention, there is provided a process for producing a heterologous multichain polypeptide or protein in a single host cell, which comprises transforming the host cell with DNA sequences coding for each of the polypeptide chains and expressing said polypeptide chains in said transformed host cell. According to another aspect of the present invention there is provided as a product of recombinant DNA technology an Ig heavy or light chain or fragment thereof having an intact variable domain.; The invention also provides a process for increasing the level of protein expression in a transformed host cell and vectors and transformed host cells for use in the processes.

Title
Processes for the production of multichain polypeptides or proteins.
Application Number
EP19840301996 19840323
Publication Number
0120694 (A2)
Application Date
March 23, 1984
Publication Date
October 3, 1984
Inventor
Wood Clive Ross
Emtage John Spencer
Kenten John Henry
Boss Michael Alan
Assignee
Celltech
GB
IPC
C12R 01/865
C12R 01/19
C12R 01/125
A61K 47/00
C07H 21/00
G01N 33/531
C12P 21/08
C12P 21/02
C12P 21/00
C12N 15/63
C12N 15/13
C12N 15/09
C12N 15/00
C12N 05/10
C12N 01/21
C12N 01/20
C12N 01/19
C12N 01/18
C12N 01/15
C07K 19/00
C07K 16/46
C07K 16/18
C07K 16/00
C07K 14/00
C07H 21/04
C07H 01/00
B01D 15/08
A61P 07/00
A61K 39/395
A61K 39/00
A61K 38/00
G01N 33/577
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