0072013-A1 is referenced by 2 patents and cites 5 patents.

Pyrrole compounds of the structural formula: or a pharmaceutically acceptable salt, ester or amide thereof have been prepared via hydrolysis of a precursor-ester after high temperature decarboxylation of from direct acidic decarboxylation of a precursor diacid. In the above formula, Ar is phenyl, substituted phenyl, pyridyl, pyrryl, substituted pyrryl, furyl or thienyl; R is, e.g., hydrogen, loweralkyl, lowercycloalkyl, lower(cycloalkyl-alkyl), loweralkenyl or halo-loweralkyl; R is hydrogen or loweralkyl; R is hydrogen, loweralkyl or halo; R is, e.g., hydroxy, loweralkoxy, substituted loweralkoxy, amino, substituted amino, morpholinyl, glucosamino or heterocyclyl-oxy; X is (CH2)0-10-, -COCH2- or -CH2CO-; and Y is oxygen, sulfur, sulfinyl, sulfonyl, CH2 or H with the proviso that when Y is CH2-, Ar can only be pyrryl, and when Y is H, Ar is pyrryl and R is not present. The compounds are analgesic and anti-inflammatory agents of high activities out low ulcerogenic side effects.

Title
Pyrrole compounds as anti-inflammatory and analgesic agents.
Application Number
EP19820107173 19820809
Publication Number
0072013 (A1)
Application Date
August 9, 1982
Publication Date
February 16, 1983
Inventor
Dorn Conrad P
Chang Michael N
Doherty James B
Assignee
Merck & Co
US
IPC
C07D 409/06
C07D 401/06
C07D 207/337
A61K 31/40
C07D 207/36
C07D 409/00
C07D 401/00
C07D 207/00
A61P 29/00
A61P 25/00
A61K 31/4427
A61K 31/44
A61K 31/4025
A61K 31/40
C07D 409/06
C07D 401/06
C07D 207/36
C07D 207/34
C07D 207/337
A61P 29/00
A61P 25/04
A61K 31/4433
A61K 31/4427
A61K 31/44
A61K 31/4025
A61K 31/40
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