0068460-A1 is referenced by 3 patents and cites 2 patents.

Compounds having the structural formula: are disclosed wherein there are 0-4 R groups and R is e.g. hydrogen, lower alkyl, halo-loweralkyl, hydroxy, lower alkoxy, halo, lower alkylthio or lower alkylsulfinyl; R is e.g. hydrogen or lower alkyl; Z is (a) -(CH2)0-n, n being 0-10; (b) -CO(CH2)1-n; (c) -(CH2)1-n-CO-; or (d) -@@-(CH2)0-n; R is e.g. hydrogen or lower alkyl; R is hydrogen, lower alkyl, hydroxy, loveralkoxy or halo; and X-Y is eg. -O-CH2- or -S-CH2-. Those compounds have been prepared via hydrolysis of a precursor or decarboxylation of a precursor-diacid. These tricyclic compounds are found to have high analgesic and anti-inflammatory activities but low ulcerogenic side effects.

Title
Tricyclic derivatives of substituted pyrrole acids as analgesic and anti-inflammatory agents.
Application Number
EP19820105637 19820625
Publication Number
0068460 (A1)
Application Date
June 25, 1982
Publication Date
January 5, 1983
Inventor
Finke Paul E
US
Shen Tsung Ying
US
Allison Debra L
US
Witzel Bruce E
US
Dorn Conrad P
US
Doherty James B
US
Assignee
Merck & Co
US
IPC
C07D 495/04
C07D 487/04
C07D 209/70
A61K 31/55
A61K 31/385
A61K 31/38
A61K 31/365
C07D 491/044
C07D 495/00
C07D 491/00
C07D 487/00
C07D 313/00
C07D 209/00
C07D 207/00
C07D 495/04
C07D 491/044
C07D 491/04
C07D 487/04
C07D 313/08
C07D 209/70
C07D 207/34
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