0002774-A1 is referenced by 155 patents and cites 1 patents.

1. A process for the acylation of 7-amino-cephem derivatives, which comprises converting an acylating component of the formula I see diagramm : EP0002774,P20,F1 in which R**1 is alkyl having from 1 to 4 carbon atoms, phenyl, 2-furyl or thiazolyl of the formula see diagramm : EP0002774,P20,F2 in which R4 is hydroxy, amino, alkenylamino having from 2 to 4 carbon atoms, formamino or acetamino optionally substituted by chlorine, bromine, fluorine, phenoxy or by 1,3,4-thiadiazolylthio in turn substituted by methyl or amino ; R5 is hydrogen, halogen, cyano, thiocyano, hydroxy or alkoxycarbonyl having from 1 to 4 carbon atoms in the alkyl moiety ; R**2 and R**3 together are oxygen or a group of the formula VIII =N-X which preferably has the syn configuration, and in which X is hydroxy, alkoxy having from 1 to 4 carbon atoms, benzyloxy, p-chlorobenzyloxy, triphenylmethoxy, aminocarbonylmethoxy, tert-butoxycarbonylmethoxy, methoxycarbonylmethoxy, ethoxycarbonylmethoxy, cyanomethoxy, allyloxy, bromallyl-oxy, phenoxy or acyloxy having from 1 to 4 carbon atoms ; with a 1-hydroxybenzotriazole of the general formula II see diagramm : EP0002774,P20,F3 in which R**6 through R**9, being identical or different, each are hydrogen, alkyl having from 1 to 4 carbon atoms, alkoxy having from 1 to 4 carbon atoms, halogen, cyano, nitro, aminocarboxy, alkylaminocarboxy having from 1 to 4 carbon atoms in the alkyl moiety, aminosulfonyl, alkylaminosulfonyl having from 1 to 4 carbon atoms in the alkyl moiety, dialkylaminosulfonyl having from 1 to 4 carbon atoms in the alkyl moiety ; to an active derivative, and subsequently reacting the latter one with a 7-aminocephem derivative.

Title
Process for acylating 7aminocephem derivatives.
Application Number
EP19780101749 19781218
Publication Number
0002774 (A1)
Application Date
December 18, 1978
Publication Date
July 11, 1979
Inventor
Seliger Hubert
Reden Jurgen Dr
Durckheimer Walter Dr
Blumbach Jurgen Dr
Assignee
Hoechst
DE
IPC
C07D 501/06
C07D 417/12
C07D 499/12
C07D 501/00
C07D 499/00
C07D 501/20
C07D 501/06
C07D 499/44
C07D 499/12
C07D 499/00
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