Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.

Composes dindazole et compositions pharmaceutiques inhibant les proteines kinases, et procedes dutilisation de ceux-ci
Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
Publication Number
Application Date
June 30, 2000
Publication Date
January 11, 2001
Collins Michael Raymond
Wallace Michael Brennan
Varney Michael David
Thomas Christine
Teng Min
Tempczyk Russell Anna Maria
Reich Siegfried Heinz
Palmer Cynthia Louise
Luu Hiep The
Johnson Theodore Otto Jr
Johnson Michael David
Hua Ye
Cripps Stephan James
Braganza John F
Borchardt Allen J
Bender Steven Lee
Kania Robert Steven
Agouron Pharmaceuticals
Agouron Pharmaceuticals
C07D 417/06
C07D 409/06
C07D 405/06
C07D 403/12
C07D 403/04
C07D 401/14
C07D 401/12
C07D 231/56
A61P 35/00
A61K 31/4709
A61K 31/444
A61K 31/4439
A61K 31/427
A61K 31/4184
A61K 31/416
C07D 401/06
View Original Source