Novel burst-free, sustained release biocompatible and biodegradable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer as a blend of uncapped (free carboxyl end group) and end-capped forms ranging in ratios from 100/0 to 1/99.

Title
Microspheres nouvelles en poly-(lactide-glycolide) a liberation controle� a lepreuve de leclatement �
Novel "burst-free" sustained release poly-(lactide/glycolide) microspheres
Publication Number
2216371
Application Date
November 18, 1996
Publication Date
July 31, 1997
Inventor
Setterstrom Jean A
Mcqueen Charles E
Roberts F Donald
Reid Robert H
Friden Phil
Van Hamont John F
Jeyanthi Ramasubbu
Agent
RIDOUT & MAYBEE
Assignee
United States Government Represented By The Secretary Of The Army
Assignee
United States Government Represented By The Secretary Of The Army
IPC
A61K 47/30
A61K 38/17
A61K 38/10
A61K 38/09
A61K 09/66
A61K 09/50
A61K 09/16
A61K 38/16
View Original Source