A microchip loboratory system (10) and method provide fluidic manipulations for a variety of applications, including sample injection for microchip chemical separations. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis and electrochromatography are performed in channels (26, 28, 30, 32, 34, 36, 38) formed in the substrate. Analytes are loaded into a four-way intersection of channels by electrokinetically pumping the analyte through the intersection (40), followed by a switching of the potentials to force an analyte plug into the separation channel (34).

Title
Procede et dispositif de realisation de manipulations microfluides a des fins danalyse et de synthese chimique
Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis
Publication Number
2196429
Application Date
August 1, 1995
Publication Date
February 15, 1996
Inventor
Ramsey J Michael
Agent
MACRAE & CO
Assignee
Lockheed Martin Energy Systems
Assignee
Lockheed Martin Energy Systems
IPC
G05D 07/06
G01N 30/84
G01N 30/60
G01N 30/38
G01N 30/28
G01N 30/16
G01N 30/02
G01N 27/447
B29C 65/48
B29C 65/00
B01L 03/00
B01J 19/00
B01F 13/00
G01N 27/26
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