2114007 is referenced by 1 patents.

Novel compounds of formula (I) wherein A is -CH = CH-B; -C .ident. C-B; -(CH2)p-X-B, wherein p is 0-2 and X is a bond, -NH- or -S(O)0-2-; optionally substituted heteroaryl or benzofused heteroaryl; -C(O)-B; or (Ia), wherein k is 1-2; D is B'-(CH2)m C(O)-, wherein m is 1-5; B'-(CH2)q-, wherein q is 2-6; B'-(CH2)e-Z-(CH2)r-, wherein Z is -O-, -C(O)-, phenylene, -NR8- or -S(O)0-2-, e is 0-5 and r is 1-5, provided that the sum of e and r is 1-6; B'-(alkenylene)-; B'-(alkadienylene)-; B'-(CH2)t-Z-(alkenylene), wherein t is 0-3, provided that the sum of t and the number of carbon atoms in the alkenylene chain is 2-6; B'-(CH2)f-V-(CH2)g-, wherein V is cycloalkylene, f is 1-5 and g is 0-5, provided that the sum of f and g is 1-6; B'-(CH2)t-V-(alkenylene) or B'-(alkenylene)-V-(CH2)t-, provided that the sum of t and the number of carbon atoms in the alkenylene chain is 2-6; B'-(CH2)a-Z-(CH2)b-V-(CH2)d-, wherein a, b and d are 0-6, provided that the sum of a, b and d is 0-6; T-(CH2)s-, wherein T is cycloalkyl and s is 1-6; naphthylmethyl or optionally substituted heteroarylmethyl; B is optionally substituted phenyl; B' is naphthyl, optionally substituted heteroaryl or optionally substituted phenyl; R is hydrogen, fluoro, alkyl, alkenyl, alkynyl, or B-(CH2)h-, wherein h is 0-3; R4 is optionally substituted phenyl, indanyl, benzofuranyl, tetrahydronaphthyl, pyridyl, pyrazinyl, pyrimidinyl or quinolyl; are disclosed, as well as their use as hypocholesterolemic agents; the method of using compounds of formula (II), wherein R20 is optionally substituted phenyl, optionally substituted naphthyl, optionally substituted heteroaryl, or optionally substituted benzofused heteroaryl, R21, R22 and R23 are independently selected from H or R20; E, F and G are independently a bond; cycloalkylene; alkylene; alkenylene; alkynylene; a substituted alkylene, alkenylene or alkynylene chain; an interrupted alkylene, alkenylene or alkynylene chain; or an interrupted alkylene, alkenylene or alkynylene chain substituted by one or more substituents; or one of R21-E and R22-F is selected from the group consisting of halogeno, OH, alkoxy, -OC(O)R5, -NR10R11, -SH or -S(alkyl); R5 is alkyl, phenyl, R14-phenyl, benzyl or R14-benzyl; R10 and R11 are independently selected from H and lower alkyl, or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier as hypocholesterolemic agents is also disclosed.

Title
Composes beta-lactame substitues utilises comme agents hypocholesterolemiants et procedes pour leur preparation
Substituted beta-lactam compounds useful as hypocholesterolemic agents and processes for the preparation thereof
Publication Number
2114007
Application Date
July 21, 1992
Publication Date
February 4, 1993
Inventor
Vaccaro Wayne
Dugar Sundeep
Breslow Ronald
Barton Derek H R
Colon Cesar
Mcallister Timothy
Lee Junning
Tann Chou Hong
Thiruvengadam Tiruvettipuram K
Clader John W
Burnett Duane A
Agent
OGILVY RENAULT SENCRLSRL
Assignee
Schering Corporation
Assignee
Schering Corporation
IPC
C07F 07/18
C07F 07/10
C07F 07/08
C07D 413/10
C07D 409/04
C07D 405/10
C07D 405/04
C07D 403/04
C07D 401/04
C07D 205/085
C07D 205/08
A61P 03/06
A61K 31/5377
A61K 31/496
A61K 31/4427
A61K 31/397
C07D 417/04
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