Disclosed are N-(2-phosphonylmethoxyethyl) and N-(3-hydroxy-2-phosphonylmethoxypropyl) derivatives of pyrimidine and purine bases, easily accessible from such heterocyclic bases and their N-(2-hydroxyethyl) or N-(2,3-dihydroxypropyl) derivatives. Most of the compounds exhibit a marked antiviral activity against DNA-viruses and can be used in therapeutic antiviral compositions.

Title
Purines etpyrimidines n-phosphonylmethoxyalkyliques; leur emploi a des fins therapeutiques
N-phosphonylmethoxyalkyl pyrimidines and purines and therapeutic application thereof
Application Number
542404
Publication Number
1340856
Application Date
July 17, 1987
Publication Date
December 21, 1999
Inventor
Rosenberg Ivan
Holy Antonin
De Clercq Erik
Agent
BORDEN LADNER GERVAIS
Assignee
Institute Of Organic Chemistry And Biochemistry Of The Academy Of
Stichting Rega Vzw
Assignee
Rosenberg Ivan
Holy Antonin
De Clercq Erik
IPC
C07F 09/6561
A61K 31/675
C07F 09/6512
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