A B S T R A C TThiazolidinedione derivatives of the general formula: Image [wherein R1 is hydrogen or a hydrocarbon residue or hetero-cyclic residue which may each be substituted; R2 is hydrogenor lower alkyl which may be substituted by hydroxyl group;X is an oxygen or sulfur atom; Z is a hydroxylated methyleneor carbonyl; m is 0 or 1; n is an integer of 1 to 3; L andM represent independently a hydrogen atom or L and M combinewith each other to cooperate jointly to form a linkage] andtheir salts, which are novel compounds, possess blood-glucose and blood-lipid lowering actions in mammals, andare of value as a therapeutic agent for diabetes andtherapeutic agent for hyperlipemia.

Title
Derives de thiazolidinedione; preparation et utilisation
Thiazolidinedione derivatives, their production and use
Application Number
492072
Publication Number
1263655
Application Date
October 2, 1985
Publication Date
December 5, 1989
Inventor
Fujita Takeshi
Meguro Kanji
Agent
FETHERSTONHAUGH & CO
Assignee
Takeda Chemical
IPC
C07D 417/14
C07D 413/12
C07D 277/34
C07D 277/30
C07D 277/24
C07D 263/32
A61K 31/425
C07D 417/12
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