The present invention concerns novel compounds of formula (I), wherein R is C1-10alkyl, C3-7cycloalkyl or C1-6alkyl substituted with C3-7cycloalkyl; R is hydrogen or C1-6alkyl; Alk represents C1-3alkanediyl; -A- represents a bivalent radical of the formula: (a) -CH=CH-N=CH-, (b) -N=CH-N=CH-, (c) -CH=N-N=CH-, (d) -CH=CH-CH=N-; in said bivalent radicals a hydrogen atom may be replaced by C1-6alkyl; and Ar is unsubstituted phenyl; phenyl substituted with up to two substituents selected from halo, C1-6alkyl or C1-6alkyloxy; unsubstituted naphthyl; or naphthyl substituted with up to two substituents selected from halo, C1-6alkyl or C1-6alkyloxy; the stereochemically isomeric forms thereof, and the pharmaceutically acceptable acid addition salts thereof. The present invention further comprises the pharmaceutical compositions comprising compounds of formula (I), the preparation thereof as well as the use as a medicine in the treatment of hyperlipidemia.

Title
Novel triazolones as apolipoprotein-b synthesis inhibitors
Application Number
96193235
Publication Number
1181079
Application Date
April 12, 1996
Publication Date
May 6, 1998
Inventor
P A C Luyts
L J J Backx
J Heeres
Agent
ma chongde
Assignee
Janssen Pharmaceutica
IPC
C07D 405/14
C07D 405/06
A61K 31/495