A microchip apparatus and method provide fluidic manipulations for a variety of applications, including sample injection for microchip liquid chromatography. The microchip is fabricated using standard photolithographic procedures chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis and electrochromatography are performed in channels formed in the substrate. Injections are made by electro-osmotically pumping sample through the injection channel that crosses the separation channel, followed by a switching of the potentials to force a plug into the separation channel.

Title
Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis
Application Number
95195417
Publication Number
1168720
Application Date
August 1, 1995
Publication Date
December 24, 1997
Inventor
Michael J Ramsey
Agent
SHEN ZHAONAN
Assignee
Lockheed Martin Energy Systems
IPC
G01N 27/26
G01N 27/00